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Publications

Recent publications from the lab

Microbiota-derived indole-3-propionic acid regulates glucose homeostasis via remodeling of hepatic mitochondrial metabolism

Or Maalumi, Ziv Ben Moshe, Or Blank, Rachel Barkan-Michaeli, Avihu Yona and Kfir Sharabi (2026). bioRxiv

Chemokine Signaling Shapes Hepatic Lipid Homeostasis through the CXCL12/CXCR4/CXCR7 Axis.

Barkan-Michaeli, R., Fainshtein, C. A., Bar-Dagan, H., Hadar, N.,
Cinnamon, E., Stein, I., and Sharabi, K (2025). bioRxiv

 Beta cells intrinsically sense and limit their
secretory activity via mTORC1-RhoA signaling

Krell, S., Hamburg, A., Gover, O., Molakandov, K., Leibowitz, G.,
Sharabi, K., Walker, M. D., and Helman, A. (2025). Cell Rep

HDAC1 deacetylates PGC-1alpha and its inhibition improves glucose homeostasis in diet-induced obese mice

Fainshtein, C. A., Maalumi, O., De-Leon, K. E.,
Barkan-Michaeli, R., and Sharabi, K. (2025). Am J Physiol Endocrinol Metab

Small molecules targeting selective PCK1 and PGC-1alpha lysine acetylation cause anti-diabetic action
through increased lactate oxidation

Mutlu, B., Sharabi, K.*, Sohn, J. H., Yuan, B., Latorre-Muro, P., Qin, X.,
Yook, J. S., Lin, H., Yu, D., Camporez, J. P. G., Kajimura, S., Shulman, G. I.,
Hui, S., Kamenecka, T. M., Griffin, P. R., and Puigserver, P. (2024). Cell Chem Biol

Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion
by altering nucleotide metabolism

Sohn, J. H., Mutlu, B., Latorre-Muro, P., Liang, J., Bennett, C. F.,
Sharabi, K., Kantorovich, N., Jedrychowski, M., Gygi, S. P., Banks,
A. S., and Puigserver, P. (2023). Cell Metab

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